USE OF CIS-HYDROXYITRACONAZOLE IN ORDER TO AVOID SIDE-EFFECTS OF ITRACONAZOLE AND HYDROXYINTRACONAZOLE

摘要

The invention involves prophylactic methods and methods of treatment using cis-hydroxyitraconazole, a metabolic derivative of cis-itraconazole, for the treatment or prevention of microbial, particularly fungal infection and other disorders, while avoiding the concomitant liability of adverse side effects associated with the administration of cis-itraconazole. Methods of treating or preventing such infections in the brain and other areas of CNS are also disclosed.