发明名称 |
L- beta -DIOXOLANE URIDINE ANALOGS AND METHODS FOR TREATING AND PREVENTING VIRUS INFECTIONS |
摘要 |
The present invention relates to the discovery that certain beta -L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high activity against Epstein-Barr virus (EBV), Varicella-Zoster virus (VZV) and Human Herpes Virus 8 (HV-8). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus (viral growth) in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds are useful for treating EBV, VZV and HV-8 infections in humans.
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申请公布号 |
WO9820879(A1) |
申请公布日期 |
1998.05.22 |
申请号 |
WO1997US20647 |
申请日期 |
1997.11.14 |
申请人 |
YALE UNIVERSITY;THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC |
发明人 |
CHENG, YUNG-CHI;CHU, CHUNG, K.;QU, FUCHENG |
分类号 |
A61K31/506;A61P31/12;A61P35/00;A61P37/00;C07D405/04;C07F9/6558;(IPC1-7):A61K31/505;A61K31/70;C07D473/00;C07H19/10 |
主分类号 |
A61K31/506 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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