Process for preparing ((e))-methyl 2-{2-(6-(2-cyanophenoxy)-pyrimidin-4-yloxy)phenyl}-3-methoxypropenoate in the absence of copper(salt) and of (n,n)-dimethylformamide

摘要

PCT No. PCT/GB97/02793 Sec. 371 Date Jun. 10, 1999 Sec. 102(e) Date Jun. 10, 1999 PCT Filed Oct. 28, 1997 PCT Pub. No. WO98/18767 PCT Pub. Date May 7, 1998A process for preparing (E)-methyl 2-[2-(6-(-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate comprising contacting (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxypropenoate or methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropanoate with 2-cyanophenate anions, the process being conducted in the absence of copper or a copper salt and in the absence of N,N-dimethylformamide. The 2-cyanophenate anions are generated in situ by reacting 2-cyanophenol with an alkali metal carbonate.