发明名称 |
Tumor homing molecules, conjugates derived therefrom, and methods of using same |
摘要 |
The present invention provides tumor homing molecules, which selectively home to a tumor. The invention also provides methods of using a tumor homing molecule to target an agent such as a drug to a selected tumor or to identify the target molecule expressed by the tumor. The invention also provides methods of targeting a tumor containing angiogenic vasculature by contacting the tumor with a molecule that specifically binds an alpha v-containing integrin. The invention further provides molecules that can selectively home to angiogenic vasculature. In addition, the invention provides a target molecule, which is specifically bound by a tumor homing molecule and is expressed by angiogenic vasculature. The invention also provides antibodies that bind to the target molecule and peptidomimetics that competitively inhibit binding of a ligand to the target molecule. |
申请公布号 |
WO9810795(A3) |
申请公布日期 |
1998.05.22 |
申请号 |
WO1997US16086 |
申请日期 |
1997.09.10 |
申请人 |
THE BURNHAM INSTITUTE |
发明人 |
RUOSLAHTI, ERKKI;PASQUALINI, RENATA |
分类号 |
C12N15/09;A61K31/704;A61K38/00;A61K39/395;A61K47/48;A61K48/00;A61K51/08;A61P35/00;C07K14/78;C07K16/18;C12N15/10;C40B40/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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