发明名称 |
PYRIDONECARBOXYLIC ACID DERIVATIVE SUBSTITUTED BY BICYCLIC AMINO GROUP, ESTER THEREOF, SALT THEREOF, AND BICYCLIC AMINE AS INTERMEDIATE THEREFOR |
摘要 |
This invention relates to bicyclic amino group-substituted pyridonecarboxylic acid derivatives of the general formula A-Pri, esters thereof and salts thereof, wherein: Pri is a pyridonecarboxylic acid residue, and A is a bicyclic amino group represented by the following formula and joined to the 7-position of the pyridonecarboxylic acid or a position equivalent to the 7-position thereof. <CHEM> wherein R1 and R2 may be the same or different and each represents a hydrogen atom, a lower alkyl group or an amino-protecting group; R3 and R4 may be the same or different and each represents a hydrogen atom, a halogen atom, a cyano group, a hydroxyl group, an oxo group, a lower alkoxy group or a lower alkyl group; and n is an integer of 0 or 1. The above-described pyridonecarboxylic acid derivatives, esters thereof and salts thereof are useful as antibacterial agents. This invention also relates to bicyclic amine compounds useful as direct intermediates for the synthesis of the above-described pyridonecarboxylic acid derivatives. |
申请公布号 |
EP0812838(A4) |
申请公布日期 |
1998.05.20 |
申请号 |
EP19950907826 |
申请日期 |
1995.02.02 |
申请人 |
DAINIPPON PHARMACEUTICAL CO., LTD. |
发明人 |
SAKAMOTO, MASATO;CHIBA, KATSUMI;TOMINAGA, YUKIO;MINAMI, AKIRA |
分类号 |
A61K31/435;A61K31/44;A61K31/47;A61K31/535;B01D39/16;B01D47/02;B01D47/06;B01D50/00;B01D53/04;B01D53/14;B01J20/28;B60H3/06;C07D209/52;C07D401/04;C07D471/04;C07D498/06 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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