Recombinant PSA expression vectors and assays using the same

摘要

The present invention provides novel recombinant DNA expression vectors that encode prostate specific antigen or modified prostate specific antigen. The vectors allow for the expression of prostate specific antigen in an active form in human prostate cell lines transformed with these novel vectors. The transformed host cells express prostate specific antigen or precursors, derivatives, or subfragments thereof in an active form. The present invention also provides in vivo and in vitro assays for determining those compounds which modulate PSA.