| 摘要 |
Aureobasidins useful as a wide-spectrum antimycotic. They are cyclodepsipeptides composed of one hydroxy acid residue having group A<1>, three amino acid residues having groups C<1>, F<1> and H<1>, four N-methylamino acid residues having groups B<1>, D<1>, G<1> and I<1>, and one cyclic amino acid residue having E<1>. A representative example thereof is one wherein A<1> is CH3CH2CH(CH3)-, B<1> is (CH3)2CH-, C<1> is benzyl, cyclohexylmethyl, p-fluorobenzyl, benzyloxymethyl, benzyloxybenzyl, methoxybenzyl, cyclohexylmethyloxybenzyl, etc., D<1> is methyl, benzyl, hydroxymethyl, etc., E<1> is propylene, F<1> is CH3CH2CH(CH3)-, G<1> is (CH3)2CH-, H<1> is (CH3)2CHCH2-, and I<1> is (CH3)2C(OH)-. They have excellent activities against not only candida but also cryptococcus and aspergillus. |
