Cyclic peptide antifungal agents

摘要

Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I where: R', R", R"', R, R, R, R, R, R, and R<0> are as defined hereinabove; R<2> is each R<2a> is independently hydroxy, halo, nitro, amino, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy or C1-C6 alkylthio; a is 1, 2, 3 or 4; R<3> is C1-C12 alkyl, C1-C12 alkoxy or -O-(CH2)m-ÄO-(CH2)nÜp-O-(C1-C12 alkyl); m is 2, 3 or 4; n is 2, 3 or 4; and p is 0 or 1; or a pharmaceutically acceptable salt thereof.i