HYDROXYLATED METABOLITES AND DERIVATIVES OF DOXAZOSIN AS ANTI-ATHEROSCLEROSIS AGENTS

摘要

This invention relates to the use of certain hydroxylated metabolites and derivatives of doxazosin and their pharmaceutically acceptable acid addition salts for retarding the development of atherosclerosis in a mammal. Such compounds are useful for reducing atherosclerotic plaque involvement and for retarding and reducing both lipid deposition fibrosis in the development of atherosclerotic plaques.