| 摘要 |
A multiphase tablet is provided for the treatment of vascular disease, having a first phase which contains a therapeutically effective amount of isosorbide nitrate, preferably isosorbide-5-mononitrate, in a controlled release matrix comprising a hydrophobic and/or lipophilic, non-swelling, fusible carrier or diluent, and a second phase which contains a therapeutically effective amount of acetylsalicylic acid or pharmaceutically acceptable salt thereof, the second phase being adapted rapidly to disintegrate and/or being in normal release form, and wherein the tablet, when administered orally, is capable of providing therapeutic blood levels of the isosorbide nitrate over a period of at least 12 hours. |
