发明名称 |
DELAYED DELIVERY SYSTEM FOR ACID-SENSITIVE DRUGS |
摘要 |
The present invention relates to a delayed release drug delivery system containing omeprazole capable of site-specific delivery and pulsatile (bolus) kinetics for once-a-day dosage comprised of an alkaline core structure sequentially layered with suspensions of omeprazole; a separation barrier; and an enteric barrier. The separation barrier is coated with a pH-dependent enteric membrane, which is relatively insoluble in gastric fluid but rapidly to immediately soluble in intestinal fluid, whereby the drug is released in a pulsatile manner in the proximal segment of the gastrointestinal tract.
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申请公布号 |
WO9819668(A1) |
申请公布日期 |
1998.05.14 |
申请号 |
WO1997US20851 |
申请日期 |
1997.11.05 |
申请人 |
SHARMATEK, INC.;SHARMA, VINAY, K. |
发明人 |
SHARMA, VINAY, K. |
分类号 |
A61K9/50;A61K31/4439;(IPC1-7):A61K9/50;A61K31/44 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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