发明名称 |
ISOLATED TUMOR NECROSIS FACTOR RECEPTOR RELEASING ENZYME, COMPOSITIONS COMPRISING THE ENZYME AND METHODS OF THE USE THEREOF |
摘要 |
The present invention relates to methods of regulating TNF activity indirectly by regulating the activity or concentration of TNF receptor releasing enzyme (TRRE). Preferably, the TRRE activity is regulated local to the site of the condition to be treated. In the case of diseases associated with elevated levels of TNF, such as rheumatoid arthritis, TRRE is administered to the site of inflammation in an amount sufficient to decrease the local levels of TNF. In the case of diseases, such as cancer, that benefit from increased levels of TNF, the level of TRRE is decreased at the disease site.
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申请公布号 |
CA2270898(A1) |
申请公布日期 |
1998.05.14 |
申请号 |
CA19972270898 |
申请日期 |
1997.11.05 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
GATANAGA, TETSUYA;GRANGER, GALE A. |
分类号 |
C12N15/09;A61K38/00;C07K16/40;C12N9/64;C12N15/12;C12N15/57;C12Q1/02;C12Q1/37;(IPC1-7):C12N15/57;A61K39/395;G01N33/574 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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