发明名称 |
CONTRYPHAN PEPTIDES |
摘要 |
The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan residues. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa1-Cys-Xaa2-Xaa3-Glu-Pro-Trp-Cys (SEQ ID NO:1), wherein Xaa1 is Gly or des-Xaa1, Xaa2 is Pro or 4-trans-hydroxyproline and Xaa3 is DTrp or L-Trp, preferably D-Trp. The present invention is further directed to the peptides contryphan R and des-Gly1 contryphan R. In contryphan R, Xaa1 is Gly and Xaa3 is D-Trp. These contryphans are useful as anticonvulsant or neuroprotective agents.
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申请公布号 |
CA2270284(A1) |
申请公布日期 |
1998.05.14 |
申请号 |
CA19972270284 |
申请日期 |
1997.11.07 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
GRAY, WILLIAM R.;OLIVERA, BALDOMERO M.;JIMENEZ, ELSIE C.;CRUZ, LOURDES J. |
分类号 |
C12N15/09;A61K38/00;C07K7/06;C07K14/435;(IPC1-7):C07K7/64;C07H21/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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