发明名称 |
A METHOD FOR SCREENING FOR THE PRESENCE OF A GENETIC DEFECT ASSOCIATED WITH THROMBOSIS AND/OR POOR ANTICOAGULANT RESPONSE TO ACTIVATED PROTEIN C |
摘要 |
<p>Method for screening for the presence of a genetic defect associated with thrombosis and/or poor anticoagulant response to activated protein C (APC). The method is directed at detecting one or more mutations at one or more of the cleavage and/or binding sites for APC of Factor V and/or Factor Va or at Factor VIII and/or Factor VIIIa at either nucleic acid or protein level or both.</p> |
申请公布号 |
EP0696325(B1) |
申请公布日期 |
1998.05.13 |
申请号 |
EP19950909724 |
申请日期 |
1995.02.14 |
申请人 |
RIJKSUNIVERSITEIT LEIDEN |
发明人 |
BERTINA, ROGIER MARIA;REITSMA, PIETER HENDRIK |
分类号 |
G01N33/53;C07K14/745;C07K16/36;C12N15/01;C12N15/09;C12P21/08;C12Q1/37;C12Q1/68;G01N33/86;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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