| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain the subject derivative, which is an antibiotic substance, comprising a specific cephalosporin pyridinium derivative, having a strong and a wide range of antimicrobial activities and especially effective against methicillin-resistant Staphylococcus aureus(MRSA), enterococci, pneumococci, etc. SOLUTION: This compound is a new cephalosporin pyridinium derivative represented by formula I [R<1> is H, a lower alkyl, a cycloalkyl or acetyl; X is CH or N; (n) is 0, 1 or 2; (m) is 0 or 1; R<2> is H, a lower alkyl, anω- hydroxyalkyl, benzyl, a lower alkyl-(substituted)heterocyclic group or a group represented by the formula CH2 CONR<4> R<5> (R<4> and R<5> are each H, anω- hydroxyalkyl, phenyl, benzyl, naphthyl, heterocylic group, etc.)] and is useful as an antimicrobial agent, etc., effective against methicillin-resistant Staphylococcus aureus(MRSA), enterococci, pneumococci, etc. The compound is obtained by reacting a compound represented by formula II with a heterocyclic carboxylic acid compound represented by formula III (R<f> is H or an amino-protecting group).</p> |
