| 摘要 |
PCT No. PCT/FR96/00067 Sec. 371 Date Jul. 15, 1997 Sec. 102(e) Date Jul. 15, 1997 PCT Filed Jan. 16, 1996 PCT Pub. No. WO96/22278 PCT Pub. Date Jul. 25, 1996Novel farnesyl transferase inhibitors of general formula (I) <IMAGE> (I) preparation thereof and pharmaceutical compositions containing same. In general formula (I), R1 is Y-S-A1- (where Y is a hydrogen atom, an amino acid residue, a fatty acid residue, or an alkyl or alkoxycarbonyl radical, and A1 is a C1-4 alkylene radical optionally alpha -substituted in the >C(X1) (Y1,) grouping by an amino, alkylamino, alkanoylamino or alkoxycarbonylamino radical wherein the alkyl or alkanoyl portion contains 1-6 carbon atoms; each of X1 and Y1 is a hydrogen atom or X1 and Y1, taken toether with the carbon atom to which they are attached, form a >C=O grouping; R'1 is hydrogen or a C1-6 alkyl radical; X is an oxygen or sulphur atom; R2 is a C1-6 alkyl, alkenyl or alkynyl radical optionally substituted by hydroxy, alkoxy, mercapto, alkylthio, alkylsulphinyl or alkylsulphonyl.
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