| 摘要 |
Purified pili of serotype LKP9 through LKP16 and LKP18 through LKP20 from Haemophilus influenzae. There is further provided a purified multivalent intact pilus vaccine composition for protecting subjects against infections caused by piliated H. influenzae which comprises a pharmaceutically acceptable carrier and whole H. influenzae pili, designated vaccine pili, previously separated from other H. influenzae components, in an amount capable of raising the antibody level of the subject to a level sufficient to provide such protection, said vaccine comprising pili of at least one type selected from a group of pili types designated LKP9 through LKP16 and LKP18 through LKP20, said vaccine pili being agglutinable by antisera derived from LKP pili purified from at least one strain of H. influenzae. Methods of immunizing employing said vaccines are also provided.
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