发明名称 DEXTROROTATORY ISOMER OF 6-(5-CHLORO-2-PYRIDYL)-(4-METHYL-1- -PIPERAZINYL)-5-CARBONYLOXY-7-OXO-6,7-DIHYDRO-5H-PYRROLO- -[3,4-B]-PYRAZINE AND ITS PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF
摘要 FIELD: organic chemistry. SUBSTANCE: product: dextrorotatory isomer of 6-(5- -chloro-2-pyridyl)-(4-methyl-1-piperazinyl)-5-carbonyloxy-7- -oxo-6,7-dihydro-5H-pyrrolo-[3,4-b] -pyrazine and its pharmaceutically acceptable acid-additive salt. Compound is synthesized by splitting the corresponding racemate using D-(+)-O,O'-dibenzoyltartaric acid in organic solvent. Pharmaceutical composition has an active substance indicated above at effective amount and pharmaceutically acceptable additions. Compound shows tranquilizing, hypnotic and anticonvulsant properties and can be used in medicine and pharmacy. EFFECT: improved method of synthesis, enhanced effectiveness. 3 cl, 1 tblg
申请公布号 RU2110519(C1) 申请公布日期 1998.05.10
申请号 RU19930051787 申请日期 1992.01.16
申请人 发明人
分类号 A61K31/495;A61K31/497;A61P25/08;A61P25/20;C07D487/04;(IPC1-7):C07D487/04;A61K31/50 主分类号 A61K31/495
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