| 发明名称 |
IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION |
| 摘要 |
FIELD: organic chemistry. SUBSTANCE: product: new derivatives of imidazole of the formula <EMI ID=0.35 HE=12 WI=60 TI=CHI> showing antagonistic activity with respect to angiotensin-II. Pharmaceutical composition has an effective amount of an active compound of the formula indicated above and conventional special additions. The following compounds are preferable as antagonists: (R)-1-[1- -oxo-2-[4-(2-sulfobenzoyl)-amino-1H-imidazole-1-yl] -octyl] -4- -cis-(4-carboxymethylphenoxy)-L-proline and (R)-1-(1-oxo-2- -[4-(2-sulfobenzoyl)-amino-1H-imidazole-1-yl] -octyl] -4-cis- -[(4-methylenephosphonic acid)-phenoxy]-L-proline. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 7 cl, 2 tbl
|
| 申请公布号 |
RU2110515(C1) |
申请公布日期 |
1998.05.10 |
| 申请号 |
RU19930046497 |
申请日期 |
1993.06.02 |
| 申请人 |
EHLI LILLI EHND KOMPANI |
发明人 |
DONAL'D BREHDFORD BOJD;KENNET LI KHAUSER;SHERRIL LINN LAJFER;UINSTON STEHNLI MARSHALL;EHLAN DEHVID PALKOVICH;VILL'JAM PFEHJFER;JON KEVIN RIL;RICHARD LI SAJMON;MITCHELL IRVIN SHTEJNBERG;KUMIKO TAKEUTI;KENNET DZHEFF TREHSHER;TSELIA EHNN VAJTSITT;DONAL'D BREHDFORD BOJD;KENNET LI KHAUSER;SHERRIL LINN LAJFER;UINSTON STEHNLI MARSHALL;EHLAN DEHVID PALKOVICH;VILL'JAM PFEHJFER;JON KEVIN RIL;RICHARD LI SAJMON;MITCHELL IRVIN SHTEJNBERG;KUMIKO TAKEUTI;KENNET DZHEFF TREHSHER;TSELIA EHNN VAJTSITT |
| 分类号 |
C07D233/64;A61K31/41;A61K31/415;A61K31/4164;A61K31/42;A61K31/425;A61K31/44;A61K31/4427;A61K31/443;A61K31/4433;A61K31/47;A61K31/675;A61P9/00;A61P9/12;A61P13/02;A61P15/00;A61P25/28;A61P27/02;A61P27/06;A61P43/00;C07D233/58;C07D233/70;C07D233/88;C07D233/90;C07D401/06;C07D401/12;C07D401/14;C07D403/06;C07D403/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07F9/6506;C07F9/6524;(IPC1-7):C07D233/88 |
主分类号 |
C07D233/64 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
