发明名称 |
FIELD: medicinal virology |
摘要 |
SUBSTANCE: vaccine corresponds to actual virus A/Johannesburg/33/94 (H3N2) by its antigenic properties. Vaccine strain A/47/Johannesburg/94/1 is a reassortant and obtained by breeding epidemic virus A/Johannesburg/3/94 (H3N2) with cold-adapted temperature-sensitive virus A/Leningrad/134/17/57 (H2N2) as an attenuation donor. Strain is harmless for adult and children. Strain A/17/Johannesburg/94/1 is actively multiplied in developing chicken embryos at optimal temperature 32-34 C and shows temperature-sensitivity and cold-adaptability. Reassortant inherited two genes encoding surface proteins (hemagglutinin and neuraminidase) from epidemic virus and six mutant genes encoding nonglycosylated proteins from attenuation donor. Strain A/17/Johannesburg/94/1 (H3N2) is areactogenic for adult (18-20 years age) at intranasal route of administration. Vaccine strain A/17/Johannesburg/94/1 corresponds to requirements by its biological property and reactogenicity index. EFFECT: strain indicated above. 1 tbli |
申请公布号 |
RU2110277(C1) |
申请公布日期 |
1998.05.10 |
申请号 |
RU19960110707 |
申请日期 |
1996.05.30 |
申请人 |
NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT EHKSPERIMENTAL' |
发明人 |
ROMANOVA JU.R.;ALEKSANDROVA G.I.;RUDENKO L.G.;LARIONOVA N.V.;ROMANOVA JU.R.;ALEKSANDROVA G.I.;RUDENKO L.G.;LARIONOVA N.V. |
分类号 |
A61K39/145;C12N7/00;C12R1/91 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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