发明名称 VITAMIN D ANALOGUES
摘要 The present invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; R<1> and R<2> which may be the same or different, stand for hydrogen or C1-C5 hydrocarbyl; or R<1> and R<2>, taken together with the carbon atom bearing the group X, can form a C3-C8 carbocyclic ring; Q is methylene, ethylene, tri- or tetra-methylene and may optionally be substituted with an oxy group, -OR<3>, in which R<3> is hydrogen, methyl or ethyl; Y is either a single bond or C1-C2 hydrocarbylene; and one or more carbons within R<1>, R<2>, and/or Y may optionally be substituted with one or more fluorine atoms, or with a hydroxyl group. The compounds show anti-inflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.
申请公布号 WO9818759(A1) 申请公布日期 1998.05.07
申请号 WO1997DK00472 申请日期 1997.10.27
申请人 LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOEVENS KEMIS;GALVERLEY, MARTIN, JOHN;PEDERSEN, HENRIK 发明人 MARTIN JOHN CALVERLEY;PEDERSEN HENRIK
分类号 A61K31/59;A61P5/18;A61P9/12;A61P17/00;A61P17/02;A61P17/10;A61P19/08;A61P19/10;A61P25/28;A61P29/00;A61P35/00;A61P37/02;C07C401/00;(IPC1-7):C07C401/00 主分类号 A61K31/59
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