发明名称 |
INFECTIOUS CLONES OF RNA VIRUSES AND VACCINES AND DIAGNOSTICASSAYS DERIVED THEREOF |
摘要 |
The invention comprises a method for generating an infectious clone based on the genome of a positive strand RNA virus which has a genome of at least about 15 kb. The invention further comprises a method for generating an infectious clone based on the genome of an RNA virus, said method further comprising selecting infectious clones by transfecting a host cell with said recombinant nucleic acid whereby said host cell is in essence not susceptible to infection with said virus. The invention further provides modified RNA viruses and vaccines and diagnostic assays derived thereof. |
申请公布号 |
CA2272046(A1) |
申请公布日期 |
1998.05.07 |
申请号 |
CA19972272046 |
申请日期 |
1997.10.29 |
申请人 |
STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK |
发明人 |
POL, JOHANNES MARIA ANTONIUS;BOS-DE RUIJTER, JUDY NORMA ALETTA;MEULENBERG, JOHANNA JACOBA MARIA |
分类号 |
G01N33/569;A61K39/00;A61K39/12;A61P37/04;C07K14/08;C12N5/00;C12N5/10;C12N15/09;C12N15/40;C12Q1/68;(IPC1-7):C12N15/40 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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