RADICICOL DERIVATIVES

摘要

Radicicol derivatives having an antityrosine kinase activity and represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R<1> and R<2> are the same or different and each represents hydrogen, alkanoyl, alkenoyl, tert-butyldiphenylsilyl, or tert-butyldimethylsilyl; R<3> represents Y- R<5> {where Y represents optionally substituted alkylene, R<5> represents CONR<6>R<7> (where R<6> represents hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted higher alkyl, etc. and R<7> represents hydroxy, substituted lower alkyl, etc.), CO2R<12> (where R<12> represents substituted lower alkyl, optionally substituted higher alkyl, etc.), etc.}; X represents halogeno or is bonded to R<4> to represent a single bond; and R<4> is bonded to X to represent a single bond or represents hydrogen alkanoyl, etc.