Selenium Derivatives of Thyroxine and Tri-iodothyronine

摘要

Novel Selenium derivatives of thyroxine and triodothyronine have the formula: wherein M is I or H and either a) R1 is 0H or a carboxyl protecting group and R2 contains at least one Se, preferably <75>Se, atom or b) R2 is H or an amino protecting group and R, contains at least one Se, preferably <75>Se, atom. The compounds are useful in dual isotope assays of thyroid function.