摘要 |
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are alpha v beta 3 antagonists, alpha v beta 5 antagonists or dual alpha v beta 3/ alpha v beta 5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.
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申请人 |
MERCK & CO., INC.;DUGGAN, MARK, E.;HARTMAN, GEORGE, D.;HOFFMAN, WILLIAM, F.;IHLE, NATHAN, C. |
发明人 |
DUGGAN, MARK, E.;HARTMAN, GEORGE, D.;HOFFMAN, WILLIAM, F.;IHLE, NATHAN, C. |