| 摘要 |
Compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof are disclosed, wherein: A1 is -CH2R6, -OR6, N(R6)(R7), -S(O)eR13, -(C(R6)(R7))1-6-OR6, -(C(R6)(R7))1-6-N(R6)(R7) or (C(R6)(R7))1-6-S(O)eR13 and A2 is H, or A1 and A2 together are =O, =C(R6)(R7), =NOR6 or =S; Q is phenyl, naphthyl, -SR6, -N(R6)(R7), -OR6 or heteroaryl; T is H, aryl, heterocycloalkyl, heteroaryl, cycloalkyl or bridged cycloalkyl; b is 0, 1 or 2; b1 is 1 or 2; X is a bond -C(O)-, -O-, -NR6-, -S(O)e-, -N(R6)C(O)-, -C(O)N(R6)-, -OC(O)NR6-,-OC(=S)NR6-, -N(R6)C(=S)O-,-C(=NOR6)-, -S(O)2N(R6)-, N(R6)S(O)2-, -N(R6)C(O)O- or -OC(O)-; R6, R7, R8a, and R13 are H, alkyl, hydroxyalkyl, alkoxy alkyl, phenyl or benzyl; or R6 and R7, together with the nitrogen to which they are attached, form a ring; R9 and R9a independently are R6 or -OR6; Z is optionally substituted (II), wherein g is 0-3 and h is 1-4, provided the sum of h and g is 1-7; wherein the aryl, phenyl, benzyl, naphthyl, heterocycloalkyl and heteroaryl groups are optionally substituted. Methods of treating asthma, cough, bronchospasm, inflammatory diseases, and gastrointestinal disorders with said compounds, and pharmaceutical compositions comprising said compounds are disclosed.
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