发明名称 |
IMMUNOGENIC DETOXIFIED MUTANT E. COLI LT-A TOXIN |
摘要 |
An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of an E. coli heat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72 of the A subunit is mutated, preferably by substitution with Arg. The toxoid is useful as vaccine against an enterotoxigenic strain of E. coli and is produced by recombinant DNA means by site-directed mutagenesis. It is also an effective adjuvant.
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申请公布号 |
CA2268758(A1) |
申请公布日期 |
1998.05.07 |
申请号 |
CA19972268758 |
申请日期 |
1997.10.30 |
申请人 |
CHIRON S.P.A. |
发明人 |
RAPPUOLI, RINO;GIULIANI, MARZIA MONICA;PIZZA, MARIAGRAZIA |
分类号 |
A01K67/027;A61K38/00;A61K39/00;A61K39/108;A61K39/39;A61P1/12;A61P31/04;A61P37/04;C07K14/245;C12N1/21;C12N15/09;C12N15/31;C12Q1/48;C12R1/19;(IPC1-7):A61K39/108 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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