Polynucleotide sequences and vectors containing them, for use in gene therapy, the polynucleotide sequences comprising two or more therapeutic genes operably linked to a promoter and encoding a fusion protein product of the therapeutic genes. The fusion protein may be for example a tyrosine hydroxylase (TH)-DOPA decarboxylase (DD) fusion protein in either TH-DD or DD-TH order, useful for treating Parkinson's disease.
申请公布号
WO9818934(A1)
申请公布日期
1998.05.07
申请号
WO1997GB02969
申请日期
1997.10.28
申请人
OXFORD BIOMEDICA (UK) LIMITED;KINGSMAN, ALAN, JOHN;KINGSMAN, SUSAN, MARY