发明名称 |
MICROBIAL PREPARATION OF SUBSTANCES FROM AROMATIC METABOLISM/I |
摘要 |
The invention makes available, by means of an increased provision of intracellular metabolic intermediates, in particular of erythrose 4-phosphate, alternative processes for the microbial preparation of substances, in particular of aromatic amino acids such as L-phenylalanine, in which processes the activity of a transaldolase is increased in a microorganism producing these substances. In preferred embodiments of the invention, the activity of a transketolase or the activity of a transport protein for the PEP-independent uptake of a sugar and/or the activity of a kinase which phosporylates the relevant sugar are/is additionally increased. The invention also relates to gene structures, and to transformed cells carrying these gene structures, which make it possible to implement these processes in a particularly successful manner. |
申请公布号 |
CA2269800(A1) |
申请公布日期 |
1998.05.07 |
申请号 |
CA19972269800 |
申请日期 |
1997.10.17 |
申请人 |
FORSCHUNGSZENTRUM JUELICH GMBH;HOLLAND SWEETENER COMPANY V.O.F. |
发明人 |
SIEWE, RUTH;KARUTZ, MARTIN;SAHM, HERMANN;SPRENGER, GEORG;SONKE, THEODORUS |
分类号 |
C12N15/09;C07H11/04;C07K14/195;C12N1/21;C12N9/10;C12N9/12;C12N15/31;C12N15/54;C12N15/63;C12P1/00;C12P13/22;C12P19/02;C12R1/07;C12R1/13;C12R1/15;C12R1/185;C12R1/425 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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