发明名称 |
DELIVERY CONSTRUCT FOR ANTISENSE NUCLEIC ACIDS AND METHODS OF USE |
摘要 |
A novel nucleic acid construct for delivery of antisense targeting sequences is provided. The construct includes intact stem loop structures and an antisense nucleic acid. Optionally, a ribozyme nucleic acid is included in the construct. The construct is useful for inhibition of selected genes in a cell. This allele-specific targeting is also useful in combination with replacement gene therapy.
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申请公布号 |
CA2270901(A1) |
申请公布日期 |
1998.05.07 |
申请号 |
CA19972270901 |
申请日期 |
1997.10.31 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
DIETZ, HARRY C. |
分类号 |
A61K38/00;A61K48/00;C12N15/113;(IPC1-7):C07H21/02;C12N15/00;C07H21/04;A61K31/70 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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