Universal solid support oligonucleotide reagents

摘要

Oligonucleotide synthesis reagent having the following general formula are provided: wherein SS is a solid support; Y is selected from the group consisting of esters, amides and thiol esters; X is selected from the group consisting of OH, SH, NH2, and removable hydrogen protecting groups; and the dotted lines represent an aromatic ring system having at least one aromatic ring, X and Y being vicinally positioned at adjacent carbon atoms of the at least one aromatic right . The reagents are suitable for the efficient step-wise oligonucleotide synthesis and the subsequent fast cleavage and deprotection of the synthesized oligonucleotide.