发明名称 DIASTEREOMER OF 1-(ISOPROXYCARBONYLOXY)ETHYLESTER OF (6R,7R)-7- -£2-(2-AMINOTHIAZOL-4-YL)-2(Z)-METHOXYIMINO)ACETAMIDO|-3- -(METHOXYMETHYL)-3-CEFEM-4-CARBOXYLIC ACID, PREPARATION METHOD THEREOF, A PHARMACEUTICAL COMPOSITION AND USE
摘要 <p>This patent describes diastereomer of 1-(isoproxycarbonyloxy)ethylester of (6R,7R)-7-[2-(2- -aminothiazol-4-yl)-2(Z)-methoxyimino)acetamido]-3- -(methoxymethyl)-3-cefem-4-carboxylic acid with a general formula (I), salts acceptable from physiological point of view, derived based on this compound and this diasteromer in form of pure salt, from diasteremeric point of view with a general formula (II), where HX is inorganic acid selected of the group including HCl, HBr, HI, HBF4, HNO3, HClO4, H2SO4, H3PO4 or organic acid selected of the group including aliphatic or aromatic sulphonic acids. This patent also describes a procedure related to the preparation of the above mentioned diastereomers or pure salts from diastereomeric point of view, together with a pharmaceutical composition containing these compounds and utilisation of the compound with a general formula (I) or (II), pure for diastereomeric point of view, to prepare medicaments for check and control of bacterial infections.</p>
申请公布号 SK279013(B6) 申请公布日期 1998.05.06
申请号 SK19920002761 申请日期 1992.09.04
申请人 HOECHST AG 发明人 FISCHER GERD;DEFOSSA ELISABETH;GERLACH UWE;HORLEIN ROLF;KRASS NORBERT;LATTRELL RUDOLF;STACHE ULRICH;WOLLMANN THEODOR;ISERT DIETER
分类号 A61K31/545;A61K31/546;A61P31/04;C07D501/00;C07D501/06;C07D501/34;C07D501/56;(IPC1-7):C07D501/34 主分类号 A61K31/545
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