GLYCOPROTEIN OF HCMV, HCMV VACCINE AND ITS PRODUCTION

摘要

PROBLEM TO BE SOLVED: To obtain the subject new glycoprotein useful for producing a vaccine for cytomegalovirus(CMV), comprising a glycoprotein B polypeptide end cut form fragment containing an epitope to be immunologically reacted with a CMV neutralizing antibody. SOLUTION: This new CMV glycoprotein B(gB) polypeptide C end cut form fragment contains an epitope to be immunologically reacted with a cytomegalovirus(CMV) neutralizing antibody and is useful for producing a vaccine effective for human cytomegalovirus (HCMV). The HCMV glycoprotein fragment is obtained by separating a genome DNA from HCMV, cutting out a gene from HindIIIF fragment, transducing the gene into a vaccinia virus vector, transfecting the gene into a mammalian host and expressing.