发明名称 Selective inhibitors of biogenic amine transporters
摘要 The present invention provides a compound having the structure: <IMAGE> wherein X, Y, and Z are independently H, Cl, Br, F, OCH3, I, or an alkyl group having 1 to 6 carbon atoms; and R is <IMAGE> wherein n is 0 to 6, X' and Y' are independently H, Cl, F, CH3, C2H5, C3H7, C4H9, OCH3, OH, CF3, OCF3, NO2, NH2, N(CH3)2, NHCOCH3, NCS, NHCOCH2Br, or N3, and (CH2)n, if present, may be substituted with OH, OCH3, or an alkyl or alkenyl group having 1 to 3 carbon atoms. The present invention also provides a pharmaceutical composition comprising the compound above and a pharmaceutically acceptable carrier. The present invention further provides a method for treating a disease characterized by a dopamine deficiency which comprises administering to a subject in need of such treatment an amount of the pharmaceutical composition above effective to treat the disease.
申请公布号 US5747503(A) 申请公布日期 1998.05.05
申请号 US19960746517 申请日期 1996.11.12
申请人 THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;RESEARCH TRIANGLE INSTITUTE 发明人 ROTHMAN, RICHARD;CARROLL, FRANK I.;BLOUGH, BRUCE;MASCARELLA, SAMUEL W.
分类号 C07D487/18;A61K31/40;A61K31/403;A61K31/435;A61P25/00;A61P25/24;A61P25/26;A61P43/00;C07D209/58;C07D209/70;C07D451/00;C07D471/08;(IPC1-7):C07D221/22;A61K31/46 主分类号 C07D487/18
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