摘要 |
Diaza-18-crown-6 compounds of the formula I: <IMAGE> I wherein X is a phenol, naphthol or quinolinol moiety selected from those of the formulae: ndependently selected from hydrogen, halo, cyano, nitro, (C1-C6) alkyl, (C2-C8) acyl, acetamido, mercapto, alkyl or arylsulfonyl, trifluoromethyl, aryl, and substituted aryl wherein the aryl moiety is selected from phenyl and naphthyl and the aryl substituent is selected from halo, cyano, nitro, (C1-C6) alkyl, (C2-C8) acyl, phenyl, acetamido, mercapto, alkyl or arylsulfonyl and trifluoromethyl; provided that when R1, R2, R3 and R5 are hydrogen and X is phenol, R4 is not nitro; and provided that when X is phenol and R5 is hydrogen, R1 (or R2) and R4 are not both nitro. Compounds of the above formula are useful as chromoionophores for the detection of calcium ions in solution or dry assays, but are of particular advantage when used in dry, thin-film multilayer analytical elements.
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申请人 |
JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. |
发明人 |
WEBER, II, WAYNE WOODROW;MESSING, CALVIN ROMAN;LOGAN, MARGARET ELIZABETH |