发明名称 |
Method for increasing the electrotransport flux of polypeptides |
摘要 |
Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming alpha -helical or beta -sheet segments. In particular, amino acid residues known to stabilize alpha -helical and beta -sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided.
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申请公布号 |
US5747453(A) |
申请公布日期 |
1998.05.05 |
申请号 |
US19950468275 |
申请日期 |
1995.06.06 |
申请人 |
ALZA CORPORATION |
发明人 |
HOLLADAY, LESLIE A.;OLDENBURG, KEVIN R. |
分类号 |
C12N15/09;A61K9/00;A61K38/00;A61K38/22;A61K38/55;A61N1/30;C07K1/107;C07K14/635;C07K14/815;(IPC1-7):A61K38/00;A61K38/04;C07K7/00;A01N1/30 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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