发明名称 |
Methods and compositions for secretion of heterologous polypeptides |
摘要 |
The instant invention discloses the unexpected result that mutant signal sequences with reduced translational strength provided essentially complete processing and high levels of expression of a polypeptide of interest as compared to wild type signal sequences, and that many mammalian polypeptides require a narrow range of translation levels to achieve maximum secretion. A set of signal sequence vectors provides a range of translational strengths for optimizing expression of a polypeptide of interest.
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申请公布号 |
US5747662(A) |
申请公布日期 |
1998.05.05 |
申请号 |
US19950398617 |
申请日期 |
1995.03.01 |
申请人 |
GENENTECH, INC. |
发明人 |
SIMMONS, LAURA C.;YANSURA, DANIEL G. |
分类号 |
C07K14/245;C12N15/70;(IPC1-7):C07H21/04 |
主分类号 |
C07K14/245 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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