Replication-defective adenoviruses for cancer immunotherapy

摘要

The invention provides compositions and methods for using replication-deflective adenoviruses and adenovirus genomes to introduce nucleic acids encoding tumor rejection antigen precursors into cells. The compositions and methods are useful for, inter alia, inducing or enhancing by in vivo or ex vivo means the immune response of a subject to tumor rejection antigens, preparation of cytolytic T lymphocytes and analysis of tumor rejection antigen precursor processing.