发明名称 |
Bacterial vaccines using vaccine strains of pathogenic bacteria |
摘要 |
Vaccines are provided for vaccinating an animal against pathogenic bacteria, including E. coli. The invention also encompasses methods of preparing and methods of use of vaccine strains and compositions that result from or are used in these methods. In particular, pathogenic bacteria comprising at least one attenuating mutation selected from the group consisting of a pyrimidine pathway mutation, an iron metabolism mutation, and a colicin transport mutation which retain their immunogenicity so as to provide protective immunity are provided.
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申请公布号 |
US5747309(A) |
申请公布日期 |
1998.05.05 |
申请号 |
US19950418520 |
申请日期 |
1995.04.07 |
申请人 |
UNIVERSITY OF SASKATCHEWAN |
发明人 |
ALLAN, BRENDA J.;POTTER, ANDREW A. |
分类号 |
A61K39/00;C07K14/245;(IPC1-7):C12N15/00;C12N1/00;C12N1/20;A61K39/108 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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