| 发明名称 |
Immunizing compositions comprising Vibrio cholerae expressing heterologous antigens |
| 摘要 |
A bacterial cell (preferably a gram-negative, enteric bacterium such as V. cholerae) the chromosome of which which contains a DNA sequence encoding a heterologous antigen, which sequence is functionally linked to an iron-regulated promoter such as the irgA promoter of V. cholerae.
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| 申请公布号 |
US5747028(A) |
申请公布日期 |
1998.05.05 |
| 申请号 |
US19950480510 |
申请日期 |
1995.06.07 |
| 申请人 |
THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
CALDERWOOD, STEPHEN B.;BUTTERTON, JOAN R.;MEKALANOS, JOHN J. |
| 分类号 |
C12N15/09;A61K39/00;C07H21/04;C07K14/245;C07K14/25;C07K14/28;C12N1/21;C12N15/74;C12P21/02;C12R1/63;(IPC1-7):C12N1/21;A61K39/106 |
主分类号 |
C12N15/09 |
| 代理机构 |
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代理人 |
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| 主权项 |
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