发明名称 |
BINDING MOLECULES AND COMPUTER-BASED METHODS OF INCREASING THE BINDING AFFINITY THEREOF |
摘要 |
The present invention features novel binding molecules and methods of improving the specific binding affinity of binding molecules, which methods do not use X-ray crystallography. For example, in one aspect, the invention features methods of making antibodies with improved specific binding affinity for a polypeptide produced during prothrombin activation. The present invention is useful for a variety of applications including, e.g., producing binding molecules with improved binding affinity; and screening for binding molecules which are in low abundance.
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申请公布号 |
WO9817792(A1) |
申请公布日期 |
1998.04.30 |
申请号 |
WO1997US17628 |
申请日期 |
1997.09.30 |
申请人 |
SUNOL MOLECULAR CORPORATION |
发明人 |
CASIPIT, CLAYTON, L.;WONG, HING, C.;HUANG, BEE, Y. |
分类号 |
G01N33/566;C07K16/00;C07K16/36;C12N15/09;G06F17/30;(IPC1-7):C12N15/11;C12N15/13;C12N15/62;G01N33/577 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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