摘要 |
Anthranilic acid derivatives of formula (I) wherein each of R to R<9> is an organic substituent, n is 0 or 1, m is 0 or an integer of 1 to 6, q is 0 or 1, X is a direct bond, O, S, -S- (CH2)p- or -O- (CH2)p- wherein p is from 1 to 6 and Ar is an unsaturated carbocyclic or heterocyclic group, and the pharmaceutically acceptable salts thereof, have activity as inhibitors of P-glycoprotein and may thus be used, inter alia, as modulators of multidrug resistance in the treatment of multidrug resistant cancers, for example to potentiate the cytotoxicity of a cancer drug.
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申请人 |
XENOVA LIMITED;RYDER, HAMISH;ASHWORTH, PHILIP, ANTHONY;ROE, MICHAEL, JOHN;BRUMWELL, JULIE, ELIZABETH;HUNJAN, SUKHJIT;FOLKES, ADRIAN, JOHN;SANDERSON, JASON, TERRY;WILLIAMS, SUSANNAH;MAXIMEN, LEVI, MICHAEL |
发明人 |
RYDER, HAMISH;ASHWORTH, PHILIP, ANTHONY;ROE, MICHAEL, JOHN;BRUMWELL, JULIE, ELIZABETH;HUNJAN, SUKHJIT;FOLKES, ADRIAN, JOHN;SANDERSON, JASON, TERRY;WILLIAMS, SUSANNAH;MAXIMEN, LEVI, MICHAEL |