发明名称 |
INDUCTION OF REV AND TAT SPECIFIC CYTOTOXIC T-CELLS FOR PREVENTION AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION |
摘要 |
The presence of cytotoxic T-cells to the Rev and/or Tat protein in samples from a subject infected with immunodeficiency virus, particularly HIV in humans, is an indication of a stable disease condition and a favourable prognosis of lack of progression to disease. Immunogenic compositions containing at least one cytotoxic T-cell epitope of the Rev and/or Tat protein of an immunodeficiency virus, particularly HIV, or a vector encoding the T-cell epitope, may be used to prevent infection by disease caused by the immunodeficiency virus, by stimulating, in the host, a specific cytotoxic T-cell response specific for the respective Rev and/or Tat proteins.
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申请公布号 |
WO9817309(A1) |
申请公布日期 |
1998.04.30 |
申请号 |
WO1997IB01402 |
申请日期 |
1997.10.17 |
申请人 |
ERASMUS UNIVERSITY ROTTERDAM;VAN BAALEN, CAREL, A.;OSTERHAUS, ALBERTUS, D., M., E. |
发明人 |
VAN BAALEN, CAREL, A.;OSTERHAUS, ALBERTUS, D., M., E. |
分类号 |
G01N33/569;A61K35/76;A61K39/00;A61K39/21;A61K48/00;A61P31/18;C07K14/16;C12N15/09;(IPC1-7):A61K39/21;A61K31/70 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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