发明名称 |
Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
摘要 |
Described are heterocyclic pyrimidine derivatives and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula:where:at least two of A-E are nitrogen, with the remaining atom(s) carbon;X=NH or NR7, such that R7=lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms);n=0, 1, 2.The remaining substituents are described in detail in the specification. |
申请公布号 |
MD960217(A) |
申请公布日期 |
1998.04.30 |
申请号 |
MD19960000217 |
申请日期 |
1995.01.23 |
申请人 |
WARNER-LAMBERT COMPANY, |
发明人 |
BRIDGES, ALEXANDER, JAMES,;DENNY, WILLIAM, ALEXANDER,;FRY, DAVID,;KRAKER, ALAN,;MEYER, ROBERT,;REWCASTLE, GORDON, WILLIAM,;THOMPSON, ANDREW, MARK, |
分类号 |
C07D487/04;A61K31/495;A61K31/4985;A61K31/505;A61K31/519;A61K31/525;A61P1/00;A61P13/02;A61P15/00;A61P17/00;A61P29/00;A61P35/00;A61P43/00;C07D239/00;C07D471/04;C07D471/14;C07D473/34;C07D487/02;C07D491/048;C07D495/04;C07D498/04;C07D513/04;(IPC1-7):A61K31/505;C07D221/00;A61K31/52 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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地址 |
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