| 摘要 |
The present invention relates to certain compounds of the formula (I) the recemic-enantiomeric mixtures and optical isomers of said compounds and the pharmaceutically acceptable salts or produgs thereof, depicted below, which are beta-adrenergic receptor agonists and accordingly have utility as, inter alia, hypoglycemic and antiobesity agents. More specifically, the compounds of the instant invention are selective agonists of beta3-adrenergic receptor. The invention also relates to methods of use for the compounds and to pharmaceutical compositions containing them. The compounds of the present invention also possess utility for increasing lean meat deposition and/or improving the lean meat to fat ratio in animals, e.g. ungulate animals, comparion animals and poultry. The compounds have the formula (see formula) wherein R1, R2, R3, R4, R5, Y and Z are as defined in the specification.
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