发明名称 |
PEPTIDE ANALOGUES CONTAINING A 7-MEMBERED LACTAM RING |
摘要 |
The invention concerns pharmaceutically useful peptide derivatives of the formula (I), P-R<1>-R<2>-R<3>-R<4>, in which P, R<1>, R<2>, R<3>, and R<4> have the various meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel peptide derivatives are of value in treating MHC class II dependent T-cell mediated autoimmune or inflammatory diseases, such as rheumatoid arthritis. The invention further concerns processes for the manufacture of the novel peptide derivatives and the use of the compounds in medical treatment.
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申请公布号 |
WO9817680(A1) |
申请公布日期 |
1998.04.30 |
申请号 |
WO1997GB02837 |
申请日期 |
1997.10.14 |
申请人 |
ZENECA LIMITED;LUKE, RICHARD, WILLIAM, ARTHUR;COTTON, RONALD |
发明人 |
LUKE, RICHARD, WILLIAM, ARTHUR;COTTON, RONALD |
分类号 |
A61K38/00;A61P29/00;A61P37/00;C07K5/09;C07K7/06;(IPC1-7):C07K7/06;A61K38/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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