Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / II

摘要

The invention makes available, by means of an increased provision of intracellular metabolic intermediates, in particular of phosphoenolpyruvate, alternative processes for the microbial preparation of substances, in particular of aromatic amino acids such as L-phenylalamine, in which processes the activity of a sugar-phosphorylating kinase is increased in a microorganism producing these substances. In preferred embodiments of the invention, the activity of a transport protein for the PEP-independent uptake of a sugar to be phosphorylated by the kinase, or the activity of a transaldolase and/or a transketolase is increased in addition. The invention also relates to gene structures, and to transformed cells carrying these gene structures, which make it possible to implement these processes in a particularly successful manner.