发明名称 |
METHOD AND CELL CULTURE FOR IDENTIFYING INHIBITORS OF EUKARYOTIC CELL PROCESSES |
摘要 |
Materials can be assayed for activity as an inhibitor of post-translational protein phosphorylation by adding the material to a growing culture of a prokaryotic organism such as a streptomycete; allowing the culture to grow for a period of time in the presence of the material; and observing the culture for altered development relative to development of the prokaryotic organism grown in the absence of the material. Observation of altered development is indicative that the material has activity as an inhibitor of posttranslational protein phosphorylation. In particular, the material to be tested can be added to a growing culture of the prokaryotic organism by placing a carrier disk bearing the material on a freshly seeded plate. Inhibition of the development of aerial mycelia and spore formation is an indicator that the material has activity as an inhibitor of post-translational protein phosphorylation.
|
申请公布号 |
CA2267616(A1) |
申请公布日期 |
1998.04.30 |
申请号 |
CA19972267616 |
申请日期 |
1997.10.17 |
申请人 |
TERRAGEN DIVERSITY INC. |
发明人 |
SAXENA, GEETA;DAVIES, JULIAN E.;WATERS, BARBARA |
分类号 |
C07K7/06;C12N1/20;C12Q1/02;C12Q1/48;C12R1/545;G01N33/50;(IPC1-7):C12N1/20 |
主分类号 |
C07K7/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|