发明名称 |
NOVEL LANTHIONINE ANTIBIOTIC COMPOSITIONS AND METHODS |
摘要 |
Certain bacteria indigenus to humans produce antimicrobial substances called bacteriocins which inhibit other bacteria, including members of their own species. Mutacins are a class of antibiotic substances made by Streptococcus mutans. Disclosed is the purification and biochemical characterization of a novel lanthionine-containing mutacin peptide from S. mutans. The purified peptide is pH- and temperature-stable and its amino acid composition indicates the presence of lanthionine and .beta.-methyllanthionine. Also provided are methods of making and using the purified polypeptide.
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申请公布号 |
CA2268744(A1) |
申请公布日期 |
1998.04.30 |
申请号 |
CA19972268744 |
申请日期 |
1997.10.22 |
申请人 |
THE UAB RESEARCH FOUNDATION |
发明人 |
CAUFIELD, PAGE W.;NOVAK, JAN |
分类号 |
C12N15/09;A61K8/00;A61K8/99;A61K38/00;A61P1/02;A61P31/04;A61Q11/00;C07K1/30;C07K14/315;C12N1/15;C12N1/21;C12N15/52;C12N15/74;(IPC1-7):C07K14/315;C07H21/04;A61K38/16;C12N15/63 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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