Retroviral vector particles having an RNA genome carrying sequences which provide in the DNA provirus at least one selected gene located within an intron in a transcription unit of the provirus, which transcription unit further comprises a polynucleotide response element responsive to a nucleus to cytoplasm transport factor such as HIV Rev. Expression of the selected genes is thus rendered Rev-dependent and so is dependent upon the presence of HIV.
申请公布号
WO9817817(A1)
申请公布日期
1998.04.30
申请号
WO1997GB02859
申请日期
1997.10.17
申请人
OXFORD BIOMEDICA (UK) LIMITED;KINGSMAN, SUSAN, MARY;KINGSMAN, ALAN, JOHN